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Your Position: Accueil > Glypican 2

Glypican 2

Brief Information

Name:Glypican-2
Target Synonym:Cerebroglycan,Glypican Proteoglycan 2, Cerebroglycan Proteoglycan
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

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Cat . Non Espèces Description du produit Structure Pureté Caractéristique
GP2-H5253 Human Human Glypican 2 / GPC2 Protein, Llama IgG2b Fc Tag
GP2-H5253-structure
GP2-H5253-sds
GP2-R52H9 Rhesus macaque Rhesus macaque Glypican 2 / GPC2 Protein, His Tag
GP2-R52H9-structure
GP2-R52H9-sds
GP2-H5255 Human Human Glypican 2 / GPC2 Protein, Fc Tag (SPR verified)
GP2-H5255-structure
GP2-H5255-sds
GP2-M52H5 Mouse Mouse Glypican 2 / GPC2 Protein, His Tag
GP2-M52H5-structure
GP2-M52H5-sds
GP2-H52H3 Human Human Glypican 2 / GPC2 Protein, His Tag
GP2-H52H3-structure
GP2-H52H3-sds
ACRO Quality

Part of Bioactivity data

GP2-H5255-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human FGF acidic, Tag Free (Cat. No. AFF-H4116) immobilized on CM5 Chip can bind Human Glypican 2, Fc Tag (Cat. No. GP2-H5255) with an affinity constant of 20.1 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol
GP2-H5255-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human Glypican 2, Fc Tag (Cat. No. GP2-H5255) on Protein A Biosensor, can bind Human FGF basic, premium grade (Cat. No. BFF-H4117) with an affinity constant of 0.3 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Synonym Name

Glypican 2,GPC2

Background

Glypican 2 (GPC2), also known cerebroglycan,  is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin-1. GPC2 silencing inactivates Wnt/?-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
GPC2 CAR-T cell therapy(Childrens Hospital of Philadelphia/Tmunity Therapeutics) TmGPC2-01-CAR-T Phase 1 Clinical The Children'S Hospital Of Philadelphia Small Cell Lung Carcinoma; Urinary Bladder Neoplasms; Neuroblastoma Details
GPC2 CAR-T cell therapy(Childrens Hospital of Philadelphia/Tmunity Therapeutics) TmGPC2-01-CAR-T Phase 1 Clinical The Children'S Hospital Of Philadelphia Small Cell Lung Carcinoma; Urinary Bladder Neoplasms; Neuroblastoma Details

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